Cortagen
AEDP · Brain Cortex Bioregulator Peptide
Cortagen is a Khavinson bioregulator tetrapeptide (AEDP) with primary effects on the brain and central nervous system. Developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology, it regulates inflammatory responses in the nervous system, restores balance between pro- and anti-oxidative processes, and stimulates interleukin-2 expression. Research shows potential benefits for ischemic brain injury recovery, nerve regeneration, and reducing autoimmune reactions affecting the CNS.
Overview
Cortagen is a Khavinson bioregulator tetrapeptide (AEDP) with primary effects on the brain and central nervous system. Developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology, it regulates inflammatory responses in the nervous system, restores balance between pro- and anti-oxidative processes, and stimulates interleukin-2 expression. Research shows potential benefits for ischemic brain injury recovery, nerve regeneration, and reducing autoimmune reactions affecting the CNS.
Cortagen works through epigenetic regulation by penetrating cell nuclei and interacting with DNA to modulate gene expression. In the heart, it affects genes including Pass1, Hsc70, Bmp2, Wnt4, Eps15, and Eps15-rs. It powerfully regulates inflammatory responses in the nervous system, helping restore proper balance between oxidative and anti-oxidative processes. Cortagen stimulates IL-2 expression and helps regulate immune function, particularly by reducing autoimmune reactions.
Research indications
What the compound has been studied for, grouped by body system. Effect size is the reported magnitude where it was measured — not a recommendation.
Shows beneficial long-term results in research following ischemic brain injury.
Research demonstrates effects on restoration of injured nerve function.
Regulates inflammatory response in the nervous system.
Helps regulate immune function by reducing autoimmune reactions.
Stimulates interleukin-2 expression for immune regulation.
Restores balance between pro- and anti-oxidative processes.
Addresses age-related CNS changes through bioregulation.
A large effect in a weak study and a small effect in a strong one are different things. Effect size is never evidence of use in people.
- Class
- Tetrapeptide bioregulator
- Chain length
- 4 residues
- Molecular weight
- 416 Da
- Typical dose
- 10-20 mg daily
- Frequency
- Once daily for 10-20 consecutive days
- Cycle length
- 10-20 days per cycle
- Storage
- Capsules: room temperature; Injectable lyophilized: 2-8°C; Reconstituted: 2-8°C refrigerated
Molecular data
- Type
- Tetrapeptide bioregulator
- Molecular weight
- 416 Da
- Chain length
- 4 residues
AEDPDosing reference
Doses reported in the literature and by suppliers. These are a record of what has been used in research — reference, never instruction.
| Context | Route | Amount | Frequency |
|---|---|---|---|
| Standard protocol | Oral capsules | 10-20 mg | Daily for 10-20 days |
| Maintenance | Oral capsules | 10 mg | 2-3 cycles yearly |
| Research protocol | IM or SubQ | 10 mg | Daily for 10 days |
Interactions
Complementary CNS bioregulators; Cortagen for cortex, Pinealon for general brain.
Often combined in comprehensive anti-aging Khavinson protocols.
Different organ targets; can be used in comprehensive bioregulator protocols.
Part of Khavinson bioregulator family; targets different tissue.
Quality checklist
- ✓White powder or capsules
- ✓Clear solution if reconstituted
- ✓Proper packaging and labeling
- !Unknown source or purity
- ×Discoloration
- ×Unusual odor
- ×Damaged packaging
What to expect
Safety
- Generally well-tolerated
- Minimal side effects reported
- Allergic reactions
- Unusual neurological symptoms
- Active neurological emergencies (seek medical care)
- Known hypersensitivity
- Pregnancy or breastfeeding
FAQ
Is Cortagen helpful for recovery after a stroke or brain injury?
Yes, Cortagen shows research evidence for beneficial effects following ischemic brain injury with long-term improvements in neurological function. It regulates inflammatory responses in nervous tissue and promotes nerve regeneration, making it relevant for post-stroke recovery protocols alongside medical rehabilitation.
How does Cortagen differ from other brain-supporting peptides like Semax?
Cortagen targets the brain cortex specifically through IL-2 stimulation and inflammatory modulation, whereas Semax acts via BDNF upregulation for cognitive effects. Cortagen is more suited for neuroinflammation and recovery, while Semax focuses on cognitive enhancement, and they're often combined in comprehensive protocols.
Can Cortagen help with autoimmune neurological conditions?
Cortagen shows potential for autoimmune modulation through IL-2 regulation and reduction of autoimmune reactions affecting the nervous system. However, the research remains preclinical. Anyone with autoimmune conditions should consult their physician before using, as immune-modulating peptides require careful monitoring.
What's the typical protocol for Cortagen as an anti-aging agent?
Standard anti-aging use involves 10-20mg daily oral capsules for 10-20 consecutive days, repeated 2-3 times yearly. Effects persist post-cycle due to epigenetic changes in gene expression. Some users prefer injectable forms for more direct delivery, though oral bioavailability is generally good for this short peptide.